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Exosomes: The Cellular Delivery Packages
Dr. Wyss-Coray explains exosomes as small vesicles that transport information between cells and their potential use in future diagnostics and treatments.
How Platelet-Rich Plasma (PRP) Actually Works
An explanation of why the FDA-approved PRP treatment is beneficial for tissue repair and sports injuries despite not containing stem cells.
The Power of Lifestyle in Alzheimer's Prevention
Dr. Wyss-Coray discusses how lifestyle factors like education, smoking, and obesity are dramatic components in the development of dementia.
Predicting Brain Aging with Synaptic Proteins
A study of 3,000 individuals reveals that a ratio of specific synaptic proteins in the brain fluid can predict cognitive resilience or decline starting in early adulthood.
The Scientific Truth About Intermittent Fasting
Dr. Wyss-Coray clarifies the lack of human clinical evidence for intermittent fasting while explaining the beneficial pathways seen in animal models.
Managing Cumulative Damage from Our Environment
A discussion on how low-level stressors like plastics and EMFs might have cumulative effects over decades and the importance of controlling what you can in your environment.
Transferring the Benefits of Exercise via Blood
Dr. Wyss-Coray reveals groundbreaking research showing that blood from exercised mice can transfer cognitive benefits to non-exercised mice, specifically through factors released from the liver like the protein clusterin.
The Real Science of Dracula
Huberman and Wyss-Coray discuss the historical lore of Dracula and bloodletting in the context of modern rejuvenation science.
Predicting ALS and Alzheimer's Through Cell Aging
Dr. Wyss-Coray reveals groundbreaking research on how measuring the age of specific cell types (muscle cells for ALS, astrocytes for Alzheimer's) can predict disease risk 15 years in advance.
Is Blood the Fountain of Youth?
Exploration of how blood contains active molecules that influence organ function and aging, rather than just being a passive readout of health.
The Truth About NMN & NAD Supplements for Longevity
Dr. Tony Wyss-Coray explains that while NMN and NAD supplements are popular, there is currently no validated human evidence that they extend lifespan, and many commercial products are unstable or mislabeled.
The Hidden Dangers of Unregulated Stem Cell Injections
Dr. Tony Wyss-Coray warns about the risks of getting stem cell treatments in countries with loose regulations and emphasizes the lack of rigorous human testing for many current offerings.
Organic vs. Non-Organic: The Pesticide Reality
Huberman discusses the surprising data regarding contaminants on organic vs. non-organic produce and the real risks associated with living near crop-spraying areas.
Why Handwriting and Physical Books Save Your Brain
Andrew Huberman discusses the 'use it or lose it' principle, specifically how handwriting and reading physical books without distractions protect neural systems from atrophy.
The Sea Squirt Lesson: Why Movement is Essential for Brain Survival
Andrew Huberman shares the fascinating story of the sea squirt to illustrate why physical movement is a biological signal to the brain that it needs to continue existing and functioning.
The 'Double Benefit' of Hating Your Workout
Explains a counterintuitive concept: doing exercise you dislike provides a unique cognitive benefit for brain structure and willpower that enjoyable exercise lacks.
Reversing Brain Aging with Young Blood
Dr. Tony Wyss-Coray explains how factors from young organisms can reactivate stem cells and improve memory in older brains.
The Wine Paradox: Social Connection vs. Alcohol
A nuanced discussion on why centenarians often drink wine despite the toxicity of alcohol, highlighting the massive health benefits of social connection.
The Dangerous Reality of Unregulated Stem Cell Injections
A cautionary tale about the severe risks of seeking unregulated stem cell treatments abroad, highlighting a case where a medical doctor was paralyzed following a spinal disc injection.
Can Young Brain Fluid Regenerate Old Brains?
Dr. Wyss-Coray shares a 'heroic' experiment where infusing young cerebrospinal fluid into old animals led to brain regeneration and cognitive improvement.
The Hidden Trade-off Between Vitality and Longevity
Andrew Huberman and Dr. Wyss-Coray discuss the 'antagonistic pleiotropy' of hormones like growth hormone and IGF-1, which can increase vitality and energy in the short term but are scientifically linked to shorter lifespans.
Why Fast-Twitch Exercise Boosts Longevity
Discussion on how explosive activities like sprinting and jumping produce unique metabolites like 'Lac-Phe' that may provide superior longevity benefits.
The Age Gap: Predicting Disease Before it Happens
Introduction to the 'Age Gap' concept where specific organs age faster than the rest of the body, serving as a predictor for future diseases.
Why Nature Stops Caring About You After Age 35
A fascinating look at the evolutionary perspective on aging, explaining that once the reproductive window closes and offspring are raised, biological pressure to maintain the organism drops significantly, leading to 'waves of aging' starting at 35.
The Hidden Danger of Forced Exercise
A fascinating study shows that while voluntary exercise is healthy, forced exercise can actually lead to stress, high blood pressure, and memory deficits.
Bright Days, Dark Nights: The Light Formula for Mental Health
Huberman breaks down the critical relationship between sunlight exposure and darkness for mental health and cortisol regulation.